Search

Automated cell classification in cancer biology is an active and challenging task for computer vision and machine learning algorithms. In this Thesis, we first compiled a vast data set composed of JIMT-1 human breast cancer cell line images, with and without therapeutic drug treatment. We then train a Convolutional Neural Network architecture to perform classification using per-cell labels obtained from fluorescence microscopy images associated with each brightfield image. The study revealed that our classification model achieves 65% accuracy in breast cancer cells under chemotherapeutic drug treatment with doxorubicin and paclitaxel. Furthermore, it reached 70% accuracy when classifying breast cancer cells without drug treatment. Our results highlight the potential of machine learning and image analysis algorithms to build new diagnosis tools.

The ideal exercise of Castellanos et al. asks IRB members to accept or deny a researchers’ request for disclosing genes associated with breast-ovarian cancer, a potential clinically significant finding (CSF), to a subgroup of 1500 research participants of a research database of 300,000 subjects. Here, we defend that researchers are under a rational duty to rescue. However, we also argue that only a decision that equally respects the rights and interests of all participants could be a fair and reasonable decision, compatible with ethics and the rule of law. Consequently, IRB members should not only accept the researchers’ request to disclose potential CFS to database participants with breast-ovarian cancer genes but also to advocate for an update in the disclosure policy for all participants of the genetic research database.

COVID-19 has brought the world to its knees, but it has brought freelance workers and artists to bankruptcy. Creativity is needed now more than ever to solve the problems of the day. Franziska Buttgereit is a mezzo-soprano who has been a member of the Freiburg Theatre's extra choir since 2010 and its first director since 2017. In 2015 she began her singing studies with Prof. Christiane Libor at the Musikhochschule Schloss Gottesaue in Karlsruhe and has been collaborating with the University of Music and the Stadttheater Freiburg, which has led to a small role in performances and the DVD production of the same name "Cendrillon" by Jules Massenet.

Below is the introduction, preface and first chapter of the book Pensar con otros. Una guía de supervivencia en tiempos de posverdad (Thinking with others. A survival guide in times of post-truth), published in 2018. A book that aims to be a starting point to break down post-truth into its main components through concrete examples, as a way to better prepare ourselves to identify the structures that foster post-truth and thus achieve, together, survival and victory. Post-truth allows facts to become facts as long as they fit the desires of each group, of each tribe. Each of these groups develops its own narrative with a language that privileges the capacity to provoke emotions, and pushes those emotions to build landscapes only accessible to those who share the way of looking at them. This discontinuity in the landscape is a threat to the existence and development of meaningful human bonds, to our coexistence as a species on this planet and, thus, to our survival.

Whether it be a surgeon or a performing artist, most people experience stage fright at some point in their lives. Varying levels of anxiety put stress on the body and impact one’s ability to perform, however, the ability to cope with a given situation leads directly to positive or negative outcomes. Franziska Buttgereit is a mezzo-soprano who has been a member of the Freiburg Theatre's extra choir since 2010 and its first director since 2017. In 2015 she began her singing studies with Prof. Christiane Libor at the Musikhochschule Schloss Gottesaue in Karlsruhe and has been collaborating with the University of Music and the Stadttheater Freiburg, which has led to a small role in performances and the DVD production of the same name "Cendrillon" by Jules Massenet.

In the continuum of evolution and adaptation of living organisms, ranging from microorganisms to human beings, there are certain cycles of time that carry with its cardinal changes that human beings must face and find the best possible harmony of eligibility. The new millennium brings with it a new lifestyle as a result of a number of determining factors, driven by technology development and the phenomenon of globalization. Therefore, we have come into a situation where a number of questions need to be raised about the necessity of redefining many daily life habits. The study presented in this paper investigated the architectural design process to consult with nature, where to many urban structures are being ruined in the name of sustainable architecture. We are constantly experiencing original situations known by intuition, but we have forgotten them, remembering the same thing can be ten times faster.

Dear JOSHA readers, once again we find ourselves saying goodbye and closing another issue. This time it is the first one for the year 2020, which is full of important changes for our non-profit journal. Among other things, we must inform you all that our editorials will be published every two months, that is, from 2020 all our issues will be published bimonthly, always on the 30th of every second month. We also like to remind that you can upload a video link of YouTube to your article!

This paper examines the economic bilateral diplomatic relationship between Nigeria and China, especially since Nigeria returned to democracy in 1999. The paper argues that while official diplomatic ties were established between the two countries as early as 1970, there was not much bilateral economic, even political, relations between them until recently. However, since 1999, which coincided with the Chinese new orientation towards Africa, there has been an exponential economic relationship between the two countries. The main question this paper grappled with is whether the relationship between the two countries is inter-dependent or not? The paper is wholly qualitative and gathered its data mainly from secondary sources. The paper is based on the dependency theory and the theory of unequal exchange.

This article presents the work of an exceptional journal from Argentina. We have had the pleasure to be working with some of the Authors of El Gato who are following the same dream as we are. This Journal shares the ideal of many scientists, the idea of exploring possible phenomena located around us as a way of understanding what we do. They, El Gato y La Caja (The Cat and The Box), is a Communication, Research and Design initiative aiming to spread to as many people as possible the idea of science not as a thing we do but as a way of observing and making sense of the world and to contribute to the construction of better, fairer societies. This journal sees the world and knowledge similar to the way JOSHA sees it, sharing and communicating Information through an open-access platform.

This paper introduces a two-path model of the invention that comprises two processes: a long-term, idea-driven path, and a short-term, problem-solving path. The model focuses on individual inventors and includes the success factors for the invention that are known from the literature. The model resumes the line of research in independent inventors and responses to five open issues that are central to current research on inventors: the role of creativity; the high level of persistence amongst inventors; the role of knowledge; the permanent transgression of domains by inventors; success criteria. The paper contains an extended review of the state of research on inventors and presents current approaches to explaining inventiveness. A core assumption of the paper is to understand the invention in the context of long-term technological development.