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The culture of the Kanuri is predominately interesting and attractive. The Kanuri people are very obsessed with their culture which help the quality of cultural traits and vibes high. In Kanuri Culture just as in other ethnic groups throughout the world there are norms and values. Even though most of their culture finds its origin in the Islamic religion, yet they have a couple of traditions that are peculiar to the tribe. One of such traditions is the application of henna, which is not well documented by the social historians and anthropologists. It is based on this assertion that this paper makes attempt to examine the application and importance of Henna among Kanuri people. Henna or “nallê” as the Kanuri call it, is a safe and temporary body art practice for millennia among the Kanuri. The technique employs a paste made from ground leaves of the henna plant (the grand leaves may be mixed with any amount of liquids or oils to create a paste) on the body or skin properly.

With this Editorial, we are closing the 5th issue of 2018. We bring you 10 articles from Countries of all over the world like Venezuela, Kosovo, Norway, Germany, and Argentina. With our first Critical Reviews with a focus on clinically relevant topics, we would like to invite our readers to comment so we can all benefit. We also like to remind our reader of our Demetrios Prize 2018. The manuscripts of the winners will soon be published in the Journal after our award committee has made its selection.

Historically, Kosovo's industry has gone through various stages of its development and fully dependent on the economic system. In general, Kosovo's industrial development was based on the exploitation of raw materials and their processing to a certain degree, but not to a satisfactory degree of processing and finalization. The diversity of industrial building design must always be in line with the requirements of technological processes, economic development, environmental protection and sustainable social development. The study presented in this paper investigated the visual organization of industrial functional compositions, focussing on urban design issues, principles according to the Gestalt laws of grouping, and sustainable urban design.

A striking benefit in overall survival was observed, and a less striking benefit in progression-free survival. This is quite in contrast to other recent studies with checkpoint inhibitors demonstrating a significant event-free survival benefit but did not demonstrate an overall survival benefit – as yet. Perhaps disease control without added toxicity is a better strategy than trying to eradicate the last cancer cells with added treatment toxicity? The innovative therapeutic strategies based on concepts of clonal evolution proposed by Cassandra Willyard (Cancer: An evolving threat, Nature 532, 166, 2016) could be of relevance here. Also, the role of type and duration of maintenance therapy should be studied further. JOSHA’S Critical Reviews in Oncology and related areas of medicine and science will focus on recently published clinical and non-clinical studies and discoveries.

ABSTRACT Sustainable Urban Development in Kosovo and Albania is subject to this research paper. Analyzes of spatial planning documents and legislation of Kosova and Albania, toward approaching New Urban Agenda, as benchmarking to sustainable development, its strategic objectives, priorities, modalities is of importance. Kosovo and Albanian cities are facing rapid urbanization due to several developmental and transitional reasons, migration, economic development challenges, initially regulated by spatial planning legislation followed by spatial planning documents. Global trends says that one third of the global population will live in cities by 2050 (UN, 2014), in Albania over two third of population will live in cities after 2035 (UN, World Urbanization Prospects, 2009 Revision). Key words: Sustainable Urban Development, Sustainable Development Goals, Inclusive Human Settlements, Resilient Cities

ABSTRACT The objective to this paper is to identify and evaluate aspects of sustainability by improving energy efficiency of traditional housing in Kosovo. The fact that refurbishment of them is to be more rational, as for sustainable and consistent use of the houses- sustainable occupancy, as for sustainable environmental protection, sustainable tourism, good practice to young urban planners, architects and real estate managers. It is acknowledged that master artisans of traditional architecture in Kosovo were conscious of the sustainability parameters in designing and constructing the traditional houses in villages and rural areas. Efficiency in the use of space, smart building location and orientation, design of the buildings, functionality of inner spaces, lay out of window openings and use of materials have been important for the traditional old buildings.

With this editorial, we are closing the fourth issue of 2018. Lookout for some new updates on our current issue. For instance, the addition of different categories for our multidisciplinary titles likes medicine, music, literature, Visual Arts. We bring you 10 articles from Countries of all over the world like Colombian, Kosovo, Italy, Saudi Arabian, Germany, Argentina, and Romania. We are proud to end this issue with our first critical Reviews about medical topics. We would like to remind our reader about our Demetrios Prize 2018. The manuscripts of the winners will be published in the Journal with a unique DOI for each paper as a chance for all those who want to have the opportunity to publish their research thesis and to win 500 Euros.

The Winter School in Biomedical Sciences is a 5 months international program at the University of Freiburg. It is designed as an intensive time of studies and research with specific and practical training that qualifies for success in academia or the private sector. In addition to the modules, students can choose a personal research project. Each research project is individually supervised and involves eight weeks of lab work, that is seven weeks of experimental work followed by a week of data analysis and a written lab report in the format of a scientific research publication.

JOSHA´S CONCLUSION. IMPORTANT PROGRESS; ESPECIALLY FOR PATIENTS WITH SARCOMAS FOR WHOM VERY FEW TREATMENT ALTERNATIVES EXIST. TRK-FUSION TESTING SHOULD BECOME ROUTINE IN PATIENTS WITH SARCOMA AND SELECTED PATIENTS WITH OTHER REFRACTORY MALIGNANCIES. JOSHA’S Critical Reviews in Oncology and related areas of medicine and science will focus on recently published clinical and non-clinical studies and discoveries. Our editors feel that there is a strong need for expert opinions on studies and discoveries that may potentially impact on patient care. While any judgment will, of course, be a personal and subjective opinion of our editors with all its limitations, we do hope this service will be helpful for our readers and stimulate thoughts and reflections in face of ever more rapid introductions of new drugs and therapeutic strategies in these days. We do encourage comments by our readers! The photo on the cover: Kinetic art by Carlos Cruz Diez . (re-edited at 12.05.18)

THESE INTERIM RESULTS OF TWO PHASE I/II TRIALS ARE REMARKABLE. THOMPSON AND COLLEAGUES DEMONSTRATE THE PROGRESS OF CLINICAL GENE THERAPY FOR MONOGENETIC DISEASES WITH A MEDIAN OBSERVATION TIME OF 26 MONTHS. WITH A FURTHER REDUCTION IN TRANSPLANT-ASSISTENSIVE CONDITIONING, THIS POTENTIALLY CURATIVE TREATMENT OF BETA-THALASSEMIA MIGHT BECOME STANDARD OF CARE IN THE FUTURE NOT LIMITED TO HIGH-INCOME COUNTRIES. HOWEVER, LONG-TERM FOLLOW -UP DATE ARE STILL NEEDED. JOSHA’S Conclusion: IMPORTANT PROGRESS – MAY BE APPLIED AS STANDARD OF CARE FOR SELECTED PATIENTS. JOSHA’S Critical Reviews in Oncology and related areas of medicine and science will focus on recently published clinical and non-clinical studies and discoveries. Our editors feel that there is a strong need for expert opinions on studies and discoveries that may potentially impact on patient care.