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Published in Volume 11, Issue 4 -

Editorial Volume 11, Issue 4

Stephan Seiler

Languages: English

DOI: 10.17160/josha.11.4.997

Dear josha-journal readers, In this editorial, I would particularly like to recommend an article by Josha's editors, in which they emphasize the many opportunities the journal offers to publish qualified articles free of charge. This is especially true for global collaboration and knowledge sharing. The journal's mission is aligned with that of the Bill & Melinda Gates Foundation. Just as the Gates Foundation seeks to expand access to important research and its impact, JOSHA strives to make knowledge accessible to all, to foster collaboration, and to advance research for the benefit of society. In this context, the current issue of the journal features three articles by Usman Al-Amin, who takes an in-depth look at education in Nigeria, identifying problems and solutions. The other articles, ranging from cancer research to the treatment of anxiety disorders, are also highly recommended! Enjoy the read!


347 304
Published in Volume 11, Issue 3 -

The Dysregulation of the Secretome in the Tumor Microenvironment: A Potential Source for Biomarker Discovery and Personalized Cancer Treatment

Jacqueline Bersano

Languages: English

DOI: 10.17160/josha.11.3.991

The cancer secretome includes all proteins released by cancer cells and the components of the tumor microenvironment. Dysregulation of secretome emerged as a major contributor to cancer initiation and progression. Cancer cells and stromal cells communicate through different secretory pathways and work together to promote tumor growth. Understanding how this tumor-stroma crosstalk drives cancer development and studying changes in the secretome can help identify new biomarkers and therapeutic targets. Considering the challenges in diagnosing several cancer types in the early stages and providing personalized treatment, it is crucial to thoroughly study cancer processes and their key players to develop effective biomarkers and targeted treatments.


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Published in Volume 11, Issue 3 -

Reshaping the Academic Landscape: JOSHA’s Shared Vision with the Gates Foundation

Neher Aseem Parimoo, Cinthya Souza Simas, Ivan Acevedo Monterrosa et al.

Languages: English

DOI: 10.17160/josha.11.3.987

The dissemination of knowledge through scientific articles is undoubtedly essential in the field of science, yet the costs linked with publication fees in reputable journals may hinder less privileged groups. These disparities pose a widespread global challenge that affects science as well. Acknowledging this issue, organizations like the Bill & Melinda Gates Foundation and the United Nations have taken steps to address these challenges. The Bill & Melinda Gates Foundation promotes rapid and equitable sharing of breakthroughs through initiatives like the Open Access Policy. Meanwhile, the United Nations advocates for the Sustainable Development Goals (SDGs) which emphasize Quality Education and reducing inequalities. Just as the Gates Foundation seeks to expand access to crucial research and its impact, JOSHA strives to make knowledge accessible to everyone, encouraging collaboration and advancing research for the benefit of society.


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Published in Volume 11, Issue 3 -

Understanding Reproductive Strategies: Courtship and Copulation Behaviours of the Asiatic Wild Dog (Cuon alpinus) in Captivity

Krunal Trivedi, Soham Mukherjee

Languages: English

DOI: 10.17160/josha.11.3.986

This study offers an in-depth observation of the courtship and copulatory behaviors of the Asiatic wild dog (Cuon alpinus), also known as the dhole, within a captive environment at the Sardar Patel Zoological Park, Ekta Nagar, Gujarat. Characterized by unique vocalizations, distinct body postures, and specific initiation cues, the reproductive strategy of the dhole exhibits both complex communication and consensual mating processes. Our observations revealed notable behaviours such as mutual grooming, nuzzling, olfactory exploration, and specific tail positioning, which signify readiness and consent for mating. The study meticulously documents the mounting attempts, copulation frequency, duration, and post-copulatory affiliative behaviours, contributing valuable insights into the dhole’s reproductive behaviours.


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Published in Volume 11, Issue 3 -

Editorial Volume 11, Issue 3

Stephan Seiler

Languages: English

DOI: 10.17160/josha.11.3.985

Dear josha-journal readers, In this issue, we recommend some important medical articles. Ana Caroline Colombo and Marcio L. Rodrigues study the fungus Cryptococcus neoformans, which can lead to brain infections and is estimated to cause 500,000 deaths each year. Their study suggests that much effort is needed to improve knowledge of how C. neoformans affects brain cells so that new therapeutic tools can be developed in the near future. Ketki Kelkar Ramanan writes about the misuse of laboratory reports in India and discusses the quality of health care. Ana Clara Solon Rufino's article on the positive impact of art classes on socially disadvantaged young people in Belém, Brazil, and Josha's critical review of a publication on the link between social media and anorexia, take a medical-social direction. There is much more in this issue, including articles on artificial intelligence, Oscar Wilde, and education in northern Nigeria. Enjoy the read!


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Published in Volume 11, Issue 3 -

EU Blue Book Traineeship Report

Ivan Acevedo Monterrosa

Languages: English

DOI: 10.17160/josha.11.3.984

The Blue Book traineeship program at the European Union Institutions offers valuable insight into the inner workings and decision-making processes of the European institutions. During my tenure at the Communication Unit of the Public Health and Food Safety Department (DG SANTE), I contributed to impactful communication strategies on public health issues, including mental health and cancer. Leveraging my medical background, I crafted scientifically backed messages for high-level events, such as the World Mental Health Day conference and Europe's Beating Cancer Plan. My experience at DG SANTE reinforced the importance of inclusive communication strategies in effecting positive change.


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Published in Volume 11, Issue 2 -

Fungal Colonization of the Brain: Anatomopathological Aspects of Neurological Cryptococcosis

Ana Caroline Colombo, Marcio L. Rodrigues

Languages: English

DOI: 10.17160/josha.11.2.983

Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in the near future.


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Published in Volume 11, Issue 2 -

Verifying the Authenticity of Diagnostic Labs: Need of the Hour

Ketki Kelkar Ramanan

Languages: English

DOI: 10.17160/josha.11.2.982

In my hematological practice, I have come across several cases of blood reports signed by technician-owned labs. Despite clear MCI (Medical Council of India) guidelines stating that DMLT technicians are not authorized to sign laboratory reports, this malpractice continues. The problem with such labs is that their reports are unreliable and may have been illegally modified for various motives and gains. These technician-run labs may either be self-signed or pathologist-signed. Such labs offer tests at lower prices at the cost of poor quality reporting. People do not mind getting their tests done at these labs as long as they get a good discount. Ideally, one must visit a lab which has a qualified pathologist available to answer patient queries, discuss reports and provide guidance. Today, we as a society are extremely cautious while making even simple lifestyle choices such as organic food, chemical-free products, etc.


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Published in Volume 11, Issue 4 -

JOSHA’s Critical Review of “CAR T Cells – A New Horizon for Autoimmunity” by John D. Isaacs

Neher Aseem Parimoo, Roland Mertelsmann

Languages: English

DOI: 10.17160/josha.11.4.978

The editorial discusses the potential of CD19-targeted CAR T cell therapy in managing autoimmune diseases. Published in The New England Journal of Medicine on February 22, 2024, the author highlights a pilot study by Müller et al. revealing promising outcomes, including remission and discontinuation of immunosuppressive medication, in 15 patients with systemic autoimmunity with a single infusion. While the therapy shows potential, it is also associated with adverse effects such as cytokine-release syndrome and long-term complications. However, further research is needed to address these concerns. If confirmed through extended follow-up, CAR T cell therapy could revolutionise autoimmune disease treatment, offering a comprehensive approach to disease management.This excellent editorial from Dr. Issacs is worth reading!


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Published in Volume 11, Issue 2 -

Why We Need to Relearn How to Talk to Machines - A Snapshot of Generative AI in January 2024

Maria Kalweit, Gabriel Kalweit

Languages: English

DOI: 10.17160/josha.11.2.977

The last few years have seen incredibly rapid progress in the field of generative artificial intelligence. Talking to machines and getting answers in natural language is part of our new, elusive normal. Driven by the exponential growth of both computing power and internet-scale data, our new digital assistants are trained by estimating the most likely next element of a given context. Recent years have clearly shown that this general objective can lead to the ability to develop complex and diverse capabilities from simple principles. At the same time, however, it can lead to interesting structures in the compression of the training data and sometimes to unpredictable artefacts. The aim of this article is to shed light on the mechanisms behind current large language models and to provide guidance on how to get the best answers to a question.