Growth hormone administration patterns differently regulate epidermal growth factor signaling
Affiliation: Facultad Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina
Keywords: Growth hormone, EGF Receptor, Cancer
Categories: Life Sciences
Growth hormone (GH) is a pituitary hormone that stimulates longitudinal bone growth and induces diverse effects on cell growth, differentiation, and metabolism of proteins, lipids and carbohydrates (Herrington & Carter-Su 2001). The use of growth hormone in the endocrine practice and for the treatment of various clinical conditions is expanding. The first use of human GH (hGH) was replacement therapy in children with GH deficiency (GHD). However, further indications have been gradually approved or proposed since the development of recombinant human GH (rhGH).