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4835 2082
Published in Volume 2, Issue 2 -

Cancer: A Story of Stem Cells and Evolution

Roland Mertelsmann

Languages: English

DOI: 10.17160/josha.2.2.20

Cancer is an acquired genetic disease of clonal origin. Carcinogenesis and its subsequent development follow the principles of evolution, starting with a single cell with stem cell properties and a proliferative advantage, leading to clonal expansion, clonal evolution and subsequent demise by killing the host: “Evolution gone awry”. Evolution can be divided into three essential steps: 1. “Chance” or random movement of molecules allows structures to interact. 2. Molecular affinity, “Necessity” (J. Monod, Chance and Necessity: Essay on the Natural Philosophy of Modern Biology, 1970), leads to a new structure providing novel properties and function. The 3rd step of the evolutionary processes, for which I would propose the term “Synclipse”, occurs, if the new constellation provides a biochemical and biological survival advantage, “survival of the fittest”, in a given environmental context.


2532 1539
Published in Volume 1, Issue 1 -

Table of Contents for the first issue 1/2014 of the “Journal of Science, Humanities and Arts – JOSHA”

Roland Mertelsmann

Languages: English

DOI: 10.17160/josha.1.1.11

Table of Contents for the first issue 1/2014 of the “Journal of Science, Humanities and Arts – JOSHA”


3226 1515
Published in Volume 2, Issue 1 -

Interferon-stimulated gene expression in chronic hepatitis C virus genotype 1 infected patients treated with the NS3/4A protease inhibitor faldaprevir in combination with pegylated interferon alpha-2a/ribavirin

Yakov Datsenko

Languages: English

DOI: 10.17160/josha.2.1.15

The objective of this study was to investigate the expression of selected interferon-stimulated genes (ISGs) in PBMC (peripheral blood mononuclear cell) prior and during the treatment with NS3/NS4A protease inhibitor faldaprevir plus pegylated interferon alpha-2a/ribavirin (PegIFN/RBV) in treatment-naïve and treatment-experienced chronic hepatitis C virus genotype 1 infected patients. This thesis was performed in three consecutive steps. First, we selected 95 most representative ISGs based on the literature. Secondly, we selected 30 patients for the SVR-oriented exploratory screening and tested all 95 genes in these patients. Finally, we tested 15 genes identified during the SVR-oriented exploratory screening in all patients eligible for this study (N = 263). As a result, we identified 15 genes which may play a role in the treatment response to faldaprevir plus PegIFN/RBV. Five ISGs (IFNA4, DDX58, IRF3, IFI27 and RSAD2) showed association with SVR at various time points.


4328 2035
Published in Volume 2, Issue 1 -

JOSHA - Table of Contents Volume 2 Issue 1

Gerhard G. Steinmann

Languages: English

DOI: 10.17160/josha.2.1.19

Volume 2, No. 1 / 2015, Table of Contents


2897 1653
Published in Volume 2, Issue 2 -

Episomal-Persistent DNA in Cancer and Chronic Diseases

Harald zur Hausen

Languages: English

DOI: 10.17160/josha.2.3.24

The DKFZ division Episomal-Persistent DNA in Cancer and Chronic Diseases, presently headed by Nobel prize laureate Harald zur Hausen, aims at the identification and characterization of disease-associated persistent circular DNA of infectious agents in human materials. Recent studies suggest an involvement of such agents in the development of chronic neurodegenerative diseases (Manuelidis, J. Neurovirol. (2011; 17:131–145). Besides the isolation of such DNAs, central questions are whether and in which way these DNA-sequences and their gene products contribute to the development of certain pathologies. A proof for a direct link between an infection with these agents and a specific disease may open new avenues for intervention (vaccination, identification of patients at risk and targeted therapy).


3352 1470
Published in Volume 1, Issue 1 -

A new Journal - JOSHA

Roland Mertelsmann

Languages: English

DOI: 10.17160/josha.1.1.12

We are happy to publish the first issue 1/2014 of the “Journal of Science, Humanities and Arts – JOSHA”. JOSHA  has been initiated to create a novel internet platform to access the broad diversity of important discoveries and creativity in the fields of Science, Humanities and Arts.


1853 1719
Published in Volume 2, Issue 2 -

Growth hormone administration patterns differently regulate epidermal growth factor signaling

Daniel Turyn

Languages: English

DOI: 10.17160/josha.2.2.21

Growth hormone (GH) is a pituitary hormone that stimulates longitudinal bone growth and induces diverse effects on cell growth, differentiation, and metabolism of proteins, lipids and carbohydrates (Herrington & Carter-Su 2001). The use of growth hormone in the endocrine practice and for the treatment of various clinical conditions is expanding. The first use of human GH (hGH) was replacement therapy in children with GH deficiency (GHD). However, further indications have been gradually approved or proposed since the development of recombinant human GH (rhGH).


2391 1589
Published in Volume 2, Issue 1 -

JOSHA – The Second Issue

Gerhard G. Steinmann

Languages: English

DOI: 10.17160/josha.2.1.17

By reviewing the 636 pages of the first two issues of JOSHA, the editors are proud of seeing a wide range of scientific diversity and creativity reflected in a broad interdisciplinary and multi-language approach. JOSHA is now in its pilot phase, and we do need your support as our much valued reader.


5343 3231
Published in Volume 2, Issue 1 -

Exercise, concomitant to therapy, has a positive influence on therapy-induced side-effects in patients with haematological malignancies

Fiona Streckmann

Languages: English

DOI: 10.17160/josha.2.1.14

Exercise interventions as a supportive measure in cancer therapy are becoming more and more relevant. With cancer therapy becoming more complex and effective, higher survival rates as well as longer life-spans are being achieved. Consequently, patients’ quality of life is becoming increasingly important and the management of therapy-related side-effects therefore essential. An increasing amount of studies are demonstrating, that the previously propagated rest and immobility during cancer therapy is not only counterproductive but that exercise interventions hold enormous potential regarding the management of side-effects in supportive cancer care and should therefore be taken more seriously. Especially haemato-oncological patients have to cope with many debilitating side-effects due to the disease itself, the long and complex medical therapy as well as the associated immobility.


797 2363

Hirnmetastasen und systemische Therapie, Meningeosis carcinomatosa

Lisa Isbell

Languages: English

Die Therapie von Hirnmetastasen solider Tumore und die Therapie der Meningeosis carcinomatosa stellt eine große Herausforderung da. Ein zentrales Problem ist die ausreichende Wirksamkeit systemischer Therapien im ZNS. Die folgende Präsentation fasst die Literatur zu diesem Thema zusammen, stellt experimentelle Ansätze der intrathekalen Therapie vor und gibt einen Überblick über die Rolle von zielgerichteten Therapien wie Tyrosinkinase-Inhibitoren (TKI) in der Behandlung von ZNS-Metastasen.