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JOSHA Table of Contents - Volume 3 Issue 7

Evguenia Alechine

Affiliation: University of Buenos Aires

DOI: 10.17160/josha.3.7.259

We are closing the last issue of 2016 with five novel contributions to the scientific, humanities, and arts fields. We expect that you will enjoy this last issue of the year, and we are already looking forward to giving 2017 the opportunity to surprise us with new content, authors, readers, and memberships. Since the foundation of our journal in December 2014, our articles have reached almost 120,000 views and over 95,000 downloads, and the most viewed article has reached 2,800 views and 1,800 downloads showing the reach of JOSHA published articles and the continuous growth of the JOSHA community.


Democratic reciprocity model: a justification of continued access to an investigational medicine in clinical research

Ignacio Mastroleo

Affiliation: CONICET

DOI: 10.17160/josha.3.7.257

In this paper, Dr. Mastroleo develops a normative model for the obligation of continued access to an investigational medicine towards research subjects from the perspective of social or distributive justice inspired in the theory of justice of John Rawls. He calls this the democratic reciprocity model. The original idea of the democratic reciprocity model is to claim that the obligation of continued access correlates with the right to health. Thus, within the Rawlsian framework, he argues that the moral reasons giving weight to the obligation of continued access are, indirectly, the principle of fair equality of opportunity and, directly, the duty of justice and/or the principle of fairness that apply to the members of a society understood as a system of social cooperation. INSTITUTION: CONICET, Argentina. [Article in Spanish]


Challenges of Architectural Design in relation to Environment and Air Pollution. A Case study: Prishtina’s first public parking garage

Bujar Q. Bajçinovci

Affiliation: University of Prishtina, Faculty of Civil Engineering and Architecture, Kosovo

DOI: 10.17160/josha.3.7.254

Cities are complex ecosystems with specific phenomenon directly reflected in our health, resources, economic, social and aesthetic fields. It can be conceptually considered that cities are locally and regionally specific. Urban planning is a process with a primary role to protect and use of environment, to manage spatial planning and urban infrastructure as a whole system. In relation to sustainability and implementation of multi-level law reinforcement, urban planning and design can significantly improve quality of life of their urbanites, particularly in relation to air pollution. Surely, long-term plans and strategies have been adopted in Kosovo, but the challenges will remain in implementation and in enforcement of these administrative instructions. Therefore, it is crucial to encourage every action, related to city functionality which will minimize air pollution.


Towards Simulating Carcinogenesis: Modeling and Simulating Carcinogenesis, Hematopoietic Tissue Homeostasis and Leukemogenesis

Jenny Groten, Maximilian Georg, Oliver Worm, Christoph Borner et al.

Affiliation: Institut für Molekulare Medizin und Zellforschung

DOI: 10.17160/josha.3.7.253

The previously identified cancer hallmarks (Groten et al. 2016, DOI: 10.17160/josha.3.7.252 ) were described by mathematical algorithms. Subsequently, a computational simulation of carcinogenesis has been developed. In the next step, the proposed algorithms and correlations have been tested, validated and adapted through the simulation (http://mertelsmann.psiori.com/). In a second model, we transferred the insights won from the first simulation to the simulation of hematopoiesis tissue homeostasis and leukemogenesis (http://hem-model.psiori.com/hema_simulation). Our findings indicate that the 10 “Hallmarks” proposed by Hanahan and Weinberg can be assigned to two major groups, “Growth/Apoptosis Balance” and “Genetic Fidelity, Immortality”. Modeling Hematopoiesis revealed one missing Hallmark, “Block of Differentiation”, which we propose to assign to the broader term “Stem Cell Features”.


Understanding and Controlling Cancer: The Hallmark Concept Revisited – Chance, Evolution and Entropy

Jenny Groten, Christoph Borner, Roland Mertelsmann

Affiliation: Albert-Ludwigs Universität, Freiburg

DOI: 10.17160/josha.3.7.252

The overall aim of this investigation was to identify the fundamental phenotypic traits of a cancer cell to develop an “in silico” simulation model and, vice versa redefine the identified characteristics via the established simulation model. Thus, the focus lay on visualization and interactivity of the simulation. To achieve this aim, we addressed the following objectives. In the present paper, the essential “Hallmarks of Cancer” have been identified, based on a literature review. The term “Hallmarks of Cancer” has thereby been adopted from Hanahan and Weinberg (Hanahan & Weinberg 2000; Hanahan & Weinberg 2011) and defines the most fundamental phenotypic characteristics of cancer cells, which are assumed to distinguish the latter from normal cells.


Die neronische Christenverfolgung – Persecution of Christians by the Roman Emperor Nero

Detlef Liebs

DOI: 10.17160/josha.3.7.251

In 64 AD, a fire destroyed large parts of Rome. The reigning emperor Nero, who was looking for areas to build a new palace with gardens, was suspected to be the author. He laid the blame on the generally suspicious Christians, then in Rome some hundred souls, who lived separate from all public ceremonies and celebrated their religion secretly. Humble Christians were tortured and the imperial court sentenced them as arsonists to cruel death penalties; after that whoever confessed to be a Christian was sentenced and the sentences became recognized precedents. Until the early 4th century, to be a Christian was due to death penalty without further detail. Institution: Faculty of Law, Albert Ludwigs University of Freiburg, Germany


Special Issue: Symposium “Science, Ethics and Arts”

Evguenia Alechine

Affiliation: University of Buenos Aires

DOI: 10.17160/josha.3.6.250

This special issue of JOSHA is dedicated to the coverage of the second Symposium “Science, Ethics and Arts” that took place on Friday, October 14th at the Haus zur Lieben Hand, Freiburg. This event was organized by the International Master Program in Biomedical Sciences (IMBS) with the sponsorship of JOSHA Journal. In this issue, you will find the presentations of all the invited speakers as well as a coverage of the art exhibition that took place during the symposium. PICTURE: Evguenia Alechine.


Understanding Cancer by Whole Genome Studies

Christof von Kalle

DOI: 10.17160/josha.3.6.248

The National Center for Tumor Diseases – NCT Heidelberg was founded as an exceptional alliance between the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKL-HD), the Heidelberg Medical Faculty, and German Cancer Aid (Deutsche Krebshilfe). The NCT MASTER project is situated at the interface of cancer genomics and clinical oncology to provide comprehensive molecular profiling to selected patients with unmet medical need, and to evaluate the utility of such an approach for informing choices regarding targeted therapy based on the molecular characteristics of the individual cancer. This multidisciplinary initiative has implemented a standardized workflow for patient selection, sample processing, molecular and bioinformatic analysis, technical validation of individual findings, and reporting of results through a dedicated molecular tumor board.


The Scientific, Social and Ethical Aspects of Prolonging Human Life

Christoph Borner

DOI: 10.17160/josha.3.6.249

In his presentation, Prof. Borner discusses the varied aspects of prolonging life from a scientific, social and ethical perspectives. These different aspects are reviewed leading to the following recommendations: 1. We should try to improve early diagnosis and targeted treatment regimens to make the life of elderly people more bearable and enjoyable. 2. We have to accept that, at one point, our life ends and we have to give over our spirit and achievement to the next generation. 3. Enjoy every second of your life - Carpe Diem (Roman Poet Horaz, 65 B.C.9). 4. If you want to save lives, you should remove from every person in this world their driver‘s license.


Bioethics and Philosophical Argumentation

Philippe Merz

DOI: 10.17160/josha.3.6.247

This presentation provides a philosophical introduction into the multilayered field of Bioethics. Firstly, it clarifies the somewhat confusing notion of "Bioethics", and then unfolds the key questions that bioethical debate faces today. The following third step discusses five obstacles to a broader discussion and possible solution of those bioethical problems – and gives four concluding hints to what needs to change in order to develop a more intense and open dialogue on those important challenges. PICTURE: Anna Boksa, Anja.